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KMID : 0370119950290020073
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Journal of Pharmacetical Scences Pusan University
1995 Volume.29 No. 2 p.73 ~ p.78
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Effect of the hepatotoxicants on the aldehyde dehydrogenase in rat liver
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Abstract
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WE produced in vivo hepatitis in rat by applying hepatotoxicants such as CCl4, allyl alcohol, galactosamine and phenobarbital. Then we focused on the alterations of the microsomal P450 activity, TBA reactive substances, the content of non-protein
SH and
the activities of alcohol dehydrogenase and aldehyde dehydrogenase in rat liver. Whereas the ADH activity was not altered except in the case of CCl4, the mitocondrial ad microsomal ALDH activities were decreased by the treatment of the
hepatotoxicant
and it was consistent with the increase of TBA reactive substances formation and the decrease of the non-protein SH content.
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KEYWORD
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